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SM Case Reports

Pyrexia Due to Isoniazid

[ ISSN : 2473-0688 ]

Abstract
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Received: 02-Jul-2015

Accepted: 21-Aug-2015

Published: 14-Sep-2015

Case Report | Volume 1 - Issue 1 | Article DOI :

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Sreenivasa Rao Sudulagunta¹, Mahesh Babu Sodalagunta², Shyamala Krishnaswamy Kothandapani³, Hadi Khorram⁴, and Mona Sepehrar⁵*

¹ Hospitalist, Columbia Asia Hospital, India
² KS Hegde Medical College, India
³ DBD Pulmonologist, Dr. B R Ambedkar Medical College, India
? Otolaryngology Department, Dr. B R Ambedkar Medical College, India
? Doctor of Pharmacy, Baptist Hospital, India

Corresponding Author:

Sreenivasa Rao Sudulagunta, Hospitalist, Columbia Asia Hospital, Kirloskar Business Park, Bangalore, India, Tel: 8147572745; Email: dr.sreenivas@live.in

Keywords

Isoniazid; Anti tuberculosis treatment; Drug fever; Allergy

Abstract

Isoniazid is one of the commonest drugs used for treatment and prophylaxis of tuberculosis especially in developing countries. The commonest adverse effects of isoniazid are mild increased liver transaminases (10-20%), peripheral neuropathy (dose-related incidence, 10-20% incidence with 10 mg/kg/d), loss of appetite, nausea, vomiting, abdominal pain and weakness. Adverse effects also include fever with rash but only fever without any other adverse effects or rash is uncommonly reported. We report a patient with pulmonary tuberculosis developing isoniazid induced pyrexia without rash with first dose of treatment. It can occur within 8 hours of starting the first dose. Patients may have drug allergies even though they might not report. High index of clinical suspicion is required for diagnosis as serology and other investigations have limited value

Citation

Sudulagunta SR, Sodalagunta MB, Kothandapani SK, Khorram H and Sepehrar M. Pyrexia Due to Isoniazid. SM J Case Rep. 2015;1(1):1005.