Keywords
Isatin; ISATIN.TSC; Chemoprevention; Therapy; Human malignancy
Abstract
Cancer is an extremely deadly disease. It is undoubtedly one of the main health concerns facing our society and on of the primary targets regarding medicinal chemistry. Even though Platinum based complexes had been in primary focus on research on chemotherapy agents, the interests in this field have shifted to non platinum based agents in order to find different metal complexes with less side effects and similar or better cytotoxicity .Thus a variety of metal complexes based on GOLD are being intensivel studied as platinum replacements. There is every need to develop these gold complexes as they are isoelectronis with platinum and these could someday become the replacement for Platinmu based anticancer Drugs.
norganic chemotherapy has been considerably boosted in recent years by the discovery and exploitation of antitumor compounds based on platinum. Some Gold (III) complexes display similar chemistry and pharnmacological activity to cis-platin and its analogues are now the basis of multimillion dollars industry and bring benefit to thousands of cancer patients. Platinum based anticancer drugs induce normal tissue toxicity particularly to the kidneys and thus alternative metal compounds are presently being evaluated in clinical trials. Gold is one of the most promising metals and its compounds are regarded as promising alternatives in cancer therapy and offer many approaches to innovative Metallopharmaceuticals.
Citation
Prakash Kinthada MMS and Gust R. Synthesis and Characterization, Nuclease Activity Studies and Anti Cancer Studies of Au (III) - Isatin Thiosemicarbazone Complexes as Potential Anticancer Drugs. SM J Pharmac Ther. 2018; 4(1): 1020s.