Keywords
Multiple sclerosis; Vein; Blood-brain barrier; Shear stress; Transmigration; Interleukin-1; VEGF
Abstract
The translation of Multiple Sclerosis from its pathological origins to its imaging manifestations has been researched extensively. We analyzed the literature surrounding the phenomenon of the central vein sign found within white matter lesions in magnetic resonance imaging of Multiple Sclerosis patients. Additionally, we linked the central vein sign with the blood-brain barrier integrity, found supporting evidence showing veins are structurally and physiologically more susceptible to inflammation. Another contributing factor we related with this radiological phenomenon is the vascular endothelium growth factor and interleukin-1. Finally, we reviewed the vascular implications during demyelination to relate the radiological representation of the central vein sign on magnetic resonance imaging with the pathogenesis of Multiple Sclerosis.
Citation
Georgiou I, Kastora SL and Murray AD. The Central Vein Sign Relationship to the Blood-Brain Barrier in Multiple Sclerosis. SM J Neurol Disord Stroke. 2017; 3(1): 1015s1.