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SM Journal of Pediatrics

The Efficacy of Anakinra in ColchicineResistant Familial Mediterranean fever: a Case Report

[ ISSN : 3067-9990 ]

Abstract
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Received: 23-Mar-2018

Accepted: 02-Apr-2018

Published: 04-Apr-2018

Case Report | Volume 3 - Issue 1 | Article DOI :

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Maha Oudrhiri*, Hanane el Ouardi, Abdelali Bentahila and Bouchra Chkirate

Department of Pediatrics, Rabat children’s hospital, Mohamed V University, Morocco

Corresponding Author:

Maha oudrhiri, Department of Pediatrics, Rabat children’s hospital, Mohamed V University, Morocco, Tel: +212661654515

Keywords

Familial Mediterranean Fever; Colchicine Resistance; Anakinra; Child

Abstract

Familial Mediterranean Fever (FMF) is an inherited autoinflammatory disease whose standard treatment is colchicine, which prevents attacks and inflammatory complications in 80 to 90% of cases. The overall rate of non-response is around 10-20%. Anti-cytokine therapies have been shown to be promising in the treatment of this disease in case of resistance to colchicine. We report the efficacy of an il-1 receptor antagonist (anakinra) in the control of febrile seizures in a child with colchicine-resistant fmf and the main reasons for considering colchicine resistance.

Citation

Oudrhiri M, el Ouardi H, Bentahila A and Chkirate B. The Efficacy of Anakinra in Colchicine-Resistant Familial Mediterranean fever: a Case Report. SM J Pediatr. 2018; 3(1): 1017.