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SM Journal of Endocrinology and Metabolism

The Expression and Activation of Extracellular Signal-Regulated Kinase-1/2 and Proliferating Cell Nuclear Antigen Content in Normal Tissue and Human Thyroid Tumors

[ ISSN : 3067-9486 ]

Abstract
Details

Received: 29-May-2015

Accepted: 31-Aug-2015

Published: 04-Sep-2015

Research Article | Volume 1 - Issue 1 | Article DOI :

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Guda BB, Pushkarev VM*, Pushkarev VV, Kovalenko A Ye, Taraschenko YM, Kovzun OI and Tronko MD

State Institution “V.P. Komisarenko Institute of Endocrinology and Metabolism of National Academy of Medical Sciences of Ukraine”, Ukraine

Corresponding Author:

Pushkarev VM, State Institution “V.P. Komisarenko Institute of Endocrinology and Metabolism of National Academy of Medical Scienced of Ukraine”, Vyshgorodska str, 69, Kyiv 04114, Ukraine, Tel: +380 44 4688998; Fax: +380 44 4303694; Email: pushkarev. vm@gmail.com

Keywords

Thyroid tumors; ERK1/2; PCNA

Abstract

Extracellular signal-regulated kinase-1/2 (ERK1/2) activation and expression and proliferating cell nuclear antigen (PCNA) content in normal tissues, benign and malignant (metastatic and not metastatic) human thyroid tumors were studied. In malignant tumors and follicular adenoma tissue increased PCNA expression was observed, and the amount of antigen in tumor tissue, except for follicular carcinoma, exceeded the amount in the conditionally normal tissue. Importantly, in encapsulated papillary carcinomas this excess was 85%, while in nonencapsulated, metastatic tumors PCNA content was on average more than 3 times above normal, and in the cases of most aggressive tumors with metastases in lungs – even 4 times. Total ERK content was significantly lower in tumors compared to normal tissue, except goiter. Activation of the ERK was almost completely suppressed in tumors but not in normal tissue. Thus, ERK activation is not associated with proliferative processes in thyroid tumor tissue. PCNA amount in thyroid tissue could serve as one of diagnostic and prognostic markers, and development of effective antigen inhibitors may be a promising trend in thyroid cancer treatment.

Citation

Guda BB, Pushkarev VM, Pushkarev VV, Kovalenko A Ye, Taraschenko YM, Kovzun OI and Tronko MD. The Expression and Activation of Extracellular Signal-Regulated Kinase-1/2 and Proliferating Cell Nuclear Antigen Content in Normal Tissue and Human Thyroid Tumors. SM J Endocrinol Metab. 2015;1(1):1002.