Keywords
Pancreatic mass; Pancreatic neuroendocrine tumors; Mixed acinar-neuroendocrine carcinoma; Differential diagnosis; Immunohistochemistry
Abstract
Diagnosis of acinar cell carcinoma (ACC) in small cytology samples can be challenging and can be confused with the diagnosis of pancreatic neuroendocrine tumors (PNET). Both tumors can present with similar cytomorphologic features, and both tumors can be presented with positivity for cytokeratin and for neuroendocrine markers. This case highlights utility of immunocytochemistry in small cytology samples not only to distinguish ACC from PNET, but also to achieve the diagnosis of the rare entity “mixed acinar-neuroendocrine carcinoma of the pancreas” (MANEC). It is our hope that reporting this case will raise awareness of including this rare possible diagnosis in the differential diagnosis of a pancreatic mass, and that continued reporting of such cases will improve efficacious diagnosis and patient outcome.
Citation
Varney J, Reber G, Nayel Y, Jackson G, Cho Y, et al. (2019) Util ity of Immunocytochemistry in Differentiating Acinar Cell Carcinoma from Neuroendocrine Tumors of the Pancreas in Small Cytology Specimens. Case Report of Mixed Acinar-Endocrine Carcinoma of the Pancreas and Review of the Literature. JSM Clin Cytol Pathol 4: 4.