Keywords
Pigmentation; Blotches, Photoaging; Brightening; Moisturizing; Safety; Eficacy; Retinoid; Cosmetic
Abstract
Objectives: To evaluate the safety and efficacy of a new regime of treatment based on the combination of two technologies: Retinsphere® and Fernblock®, topical and oral respectively, in decreasing the visibility of skin blotches and creating a more even complexion. Secondly, the anti-aging effects were also assessed.
Methods: Randomized, double blind, vehicle-controlled study. 80 women aged between 35 and 55 years old were recruited and grouped in 4 arms of 20 subjects: (A) topical single treatment, (B) oral single treatment, (C) combined (oral and topical treatment) and (D) control. Efficacy was objectively evaluated with non-invasive devices (Chromameter®, Mexameter®, Tewameter®, Corneometer®, Triplesense®, SkinSys® and DermaLab®). Baseline values were compared to outcomes obtained at T30 and T90, and also each group (A, B and C) to control group (D). Subjective assessment was performed at the end of the study by the investigator as well as the patient, using a questionnaire especially developed for this purpose. Adverse events were monitored and followed up throughout the 90-day study period.
Results: Active regimens (A, B and C) were significantly better improving skin brightness, lightening and aging signs compared to control. They were also scored positively by the investigator and the patients regarding skin lightening, wrinkle correction and firmness. The overall safety evaluation revealed good tolerance for all regimens. Two patients of combined treatment arm (C) reported mild to moderate erythema and itchiness.
Conclusions: Globally, the outcomes obtained with the combined regime (C) were superior to single treatments separately (A and B). Furthermore, subjects that received combined regimen obtained faster results, reaching better scores within the first month. This could lead to improvement of the patient’s adherence.
Citation
Truchuelo MT, Gabriel MT, Chan HP, Chan GP and Vitale M. Safety and Efficacy of a New Regimen in Homogenizing and Brightening Skin Complexion Among Filipino Women. SM Dermatolog J. 2017; 3(1): 1011.