Mycosis Fungoides (MF) is the most common primary cutaneous lymphoma. Co-expression of CD4 and CD8 in a subset of atypical T-lymphocytes of MF is rare. Herein, we reported a case of CD4/CD8 dual-positive MF in a 70-year-old man. The biopsy demonstrated significant epidermotropism of atypical, hyperchromatic, cerebriform of lymphocytes. Immunohistochemical staining revealed that the lymphoid infiltrate is CD4/CD8 double positive with CD5 and CD7-positive

The past decade has seen the change of habits in several cultures. Today, children spend more time in front of the TV or playing videogames than years ago. However, the changes experienced by these habits about near-activities over the past decade remain unprecedented. The use of mobile phone or tablet has achieved a principal role in children habits, not only to have fun, but also to study, even encouraged by teachers. It is clear that these devices provide a lot of information and a more attractive way to learn different signatures such as History or Natural Sciences. However, this change in daily routine might result in a change of strabismus pathologies of children, and ophthalmologists should be aware of it.

Letter to the Editor

“The stepmother gave her the meanest work in the house to do; she had to scour the dishes, tables, etc., and to scrub the floors and clean out the bedrooms. The poor girl had to sleep in the garret, upon a wretched straw bed, while her sisters lay in fine rooms with inlaid floors, upon beds of the very newest fashion, and where they had looking-glasses so large that they might see themselves at their full length. The poor girl bore all patiently, and dared not complain to her father, who would have scolded her if she had done so, for his wife governed him entirely.

Some medical disorders have an insidious development with an asymptomatic period which may represent the authentic therapeutic window. Probably, this is the case of the Cerebral Small Vessel Disease (CSVD). This term includes several pathological processes of different aetiologies which cause an increase of parietal thickness in arterioles, capillaries and venules. This phenomenon affects basically the basement membrane and it is associated with the narrowing of the lumen and the weakening of the wall. The consequences of these alterations are the loss of proteins to interstice and the slowness of blood flow, which increase the risk of ischemia and tissue bleeding [1,2].

Eruptive syringoma is a generalised variant of syringomas. They are rare benign tumours of the eccrine sweat ducts typically presenting asymptomatically, but occasionally with pruritus when associated with perspiration or in individuals with a background of atopy. Although treatment is usually mostly oriented to cosmetic improvement, it often proves difficult and unsatisfactory.

We present a diagnostically challenging case of eruptive syringoma in a young woman who presented atypically, with an intensely pruritic dermatosis.