Sarcoidosis, a multisystem noncaseating granulomatous disease of unknown cause, has occasionally been associated with connective tissue diseases. African Americans and women have higher rates of sarcoidosis [1,2]. Its association with dermatomyositis is uncommon and most of cases are described in Japanese patients [3-13]. We report a patient with sarcoidosis who developed dermatomyositis

Fabry’s disease is a rare X-linked lysosomal storage disorder associated with potential multiorgan dysfunction. We describe Fabry’s disease in an adult patient presenting to the Rheumatology clinic, St John’s Hospital, West Lothian, Scotland with “Raynaud’s- like” phenomenon, rash and renal impairment.

Giant Cell Arteritis (GCA) is the most common form of vasculitis in the adult population. It classically presents with new-onset headache in a patient older than 50 years, and reflects predominantly-intracranial vessel pathology. We describe a 67-year old man who presented with subacute myalgia of the lower extremities and constitutional symptoms, and was later found to have an extra-cephalic presentation of GCA. Magnetic Resonance Imaging of the lower extremities demonstrated diffusely enhanced signal intensity in the distribution of the quadriceps muscle, initially leading us to suspect an inflammatory myopathy. Muscle biopsy under radiographic guidance, however, was normal. Confronted with a middle-aged gentleman with non-specific symptoms and elevated laboratory markers of systemic inflammation, we performed a biopsy of the temporal artery and nailed the atypical, ‘silent’ form of GCA. The patient responded favorably to treatment with prednisone

Ischemic Colitis (IC) is a clinical entity that includes all secondary lesions due to circulatory anoxia of the wall of the colon and/or rectum. This complication may occur in connection with the use of many drugs. Rare forms were described in combination with chemotherapy are rather secondary to neutropenia than to chemotherapy itself. Ischemic colitis induced by Erlotinib use is an exceptional form. We describe in this report a case of ischemic colitis during treatment with Erlotinib.

Classical metastasis sites of bladder transitional cell carcinoma are nodes, liver, lung and bone. The meningeal infiltration is exceptional and it’s reported only few case reports in the literature and the majority shows that many patients had the complication occur after successful treatment of their systemic disease. We report her new case report of meningitis carcinomatous revealing bladder cancer in young woman.