Neoadjuvant chemotherapy is a mainstay in therapy for Triple Negative Breast Cancer (TNBC) and is found to decrease the nodal metastasis of the disease prior to surgical excision. Triple negative breast cancer is typically aggressive with rapid growth and poor outcomes, having high recurrence rates as well as short intervals from recurrence to death. Chemotherapy is the only systemic treatment available for TNBC patients. These patients that are treated with neoadjuvant chemotherapy successfully and attain a complete pathological response demonstrate improved survival. Inflammatory Breast Cancer (IBC) is also typically very aggressive, and rare, accounting for only 1-6% of breast cancers diagnosed in the United States. Inflammatory breast cancer is a clinical diagnosis and is typically hormone receptor negative, and HER2 positive [1]. This case presentation is that of a combination of rare, aggressive breast cancers which obtained a complete pathological response to neoadjuvant chemotherapy.

Introduction: Recurrent Soft Tissue Sarcoma (STS) of the extremity remains a difficult challenge. Isolated Limb Infusion (ILI) is a treatment option for patients with unresectable extremity STS who would otherwise require amputation. We present a case of recurrent extremity sarcoma managed with ILI as a limb-salvage alternative to amputation.

Methods: We present a case of recurrent extremity sarcoma managed with repeated ILI and a brief review of the literature.

Case Report: A 34 year old male presented in July 2013 as a referral for forequarter amputation for management of unresectable recurrent left upper extremity sarcoma. At initial presentation in 2011, the tumor involved the median nerve. Neoadjuvant radiation was administered and a microscopic margin positive resection of a single left forearm lesion was performed. The patient developed multifocal recurrence in 2013 with lesions involving the initial left forearm site, the left upper extremity along the biceps tendon, a left clavicular lesion and left axillary lymphadenopathy. CT imaging of the chest demonstrated no evidence of distant disease. Resection of the multiple recurrences was performed followed by ILI. A partial response to ILI was initially observed. Additional disease developed 9 months after ILI and repeat ILI was performed. Forequarter amputation was ultimately required for local control of additional multifocal recurrence, 16 months after initial ILI. Distant disease eventually developed to which the patient succumbed in late 2015.

Conclusion: Management of recurrent extremity STS remains a difficult challenge. Repeated ILI offers an alternative to amputation for selected patients while maintaining function and quality of life.

Lymphatic filariasis is a major health problem in many parts of tropics with India accounting for more than 1/3rd of global disease burden. Most of the cases are caused by Wuchereria bancroftii (90%) and Brugia malayi. Breast being an extra-nodal site is a rare site for occurrence of filarial nodule. Patients usually present as a solitary, non tender lump in upper outer quadrant of breast. There may be associated fever, peau d’ orange and palpable axillary lymphadenopathy and the condition may mimic malignancy. Fine Needle Aspiration Cytology (FNAC) from breast lump reveals several microfilariae with inflammatory infiltrates and giant cells. We present to you a case of an adult female from endemic area with painless solitary lump in her left breast which was later diagnosed as filarial granuloma

Introduction: Retinoblastoma is the most common intraocular tumor of the child. Metastasis to the parotid gland is very rare. There are only 5 cases previously reported in the literature and because of their rarities and the relative lack of data on their management, there is no clearly defined treatment algorithm.

Case Report: We report a case of a 4 years-old child operated for retinoblastoma who received adjuvant chemotherapy, and presented 9 months after her surgery, parotid metastasis of retinoblastoma for which she underwent a total parotidectomy with preservation of facial nerve, and lymph node dissection.

Discussion and Conclusion: The aim of this case is to discuss the clinical, Para-clinical and Pathological characteristics, confirming the poor prognosis of secondary tumors of the parotid, especially with metastatic lymph node

Introduction: Mature Cystic Teratomas (MCTs) comprise the most common subset of germ cell neoplasms, especially in the pediatric population. Presentation of this tumor in children under the age of 6 is exceedingly rare.

Case: A 2-year-old girl presented with increasing abdominal pain and distension and underwent a CT that was suspicious for a teratoma. The diagnosis was confirmed by subsequent pathological examination after postoperative removal.

Discussion: Various laboratory and imaging studies can be used to diagnose MCTs. Clinically significant complications such as ovarian torsion and impact on future fertility must be considered when planning treatment options.

Conclusion: Though not previously reported in the literature, ovarian MCTs can present in a child as young as 2 years old.