Pregabalin is a drug widely used in patients with neuropathic pain. While it may cause common adverse events such as dizziness, somnolence and peripheral edema, there are a few reports addressing a possible relationship between pregabalin and heart failure. Here we report an elderly woman with a history of heart failure New York Heart Association (NYHA) class I who was taking pregabalin presented with acute decompensated heart failure and acute kidney injury. With discontinuation of pregabalin and supportive treatment, patient’s symptoms improved rapidly and she was discharged well. Though exact mechanism is still unclear, it is believed that antagonism of the L-type calcium channels in vasculature plays a role in pregabalin induced heart failure. Current American Heart Association (AHA) guideline recommends prescribing pregabalin with caution in patients with NYHA class III to IV heart failure. From this case report, we would suggest to use pregabalin cautiously in all patients with history of heart failure (NYHA class I to IV) especially when there is co-existing renal impairment.

Recently, health accidents relief and medical dispute adjustment act (called Shin Hae-Cheol law) went into effect. Although the medical profession expressed its concern about passive treatment, the many civic groups welcome the SHC law. Of note, cases of some outcome are automatically entered into mediation process without consent of doctors or hospitals. However, this is a violation to the principal of the law. Because the law should be criteria-driven (or process-driven), not out driven. It needed that medical process should have its own predefined indication and contraindication or predefined criteria in detail if the society decided to give any legal obligation to doctors.

 Introduction: Anaphylaxis occurs worldwide and recent data from developed countries indicate a continued increase, not only in children but also in adults. In children, food allergens are the most frequent elicitors. In adults, besides food, hymenoptera venoms and drugs are frequent causes of anaphylaxis. Milk and egg are the most frequent foods involved in small children and adolescents. In the last decades, fish parasite Anisakis simplex is considered to be an important cause of food allergy among adults in Spain and Japan. At present, Anisakis simplex is one of the most important hidden food allergens in adults who suffer from anaphylaxis in these geographical areas.

Methods: This retrospective, case-based and time series study was conducted over a sixteen years period, from January 2000 to December 2016, in patients studied in our Department and diagnosed of anaphylaxis induced by Anisakis simplex. The diagnosis was confirmed with a combination of clinical data, skin tests and specific IgE determinations.

Results: A mean population prevalence of 3 cases per 100.000 inhabitants and year was recorded. The ratio of females to males was 2.5:1 and the median age was 59 years (range 18 - 88 years). Most anaphylaxis cases (65%) were treated in Emergency rooms, 12.5% of them were hospitalized and 1% admitted in Intensive Care Unit. Most patients were undertreated with H1-receptor antagonists (antihistamines) and steroids, and only 34% received injected adrenaline.

Conclusion: This study shown that Anisakis simplex induces most allergic reactions in non-atopic middle aged adults in northern Spain. Drug cofactors (NSAIDs, ACE-inhibitors and beta-blockers) are involved in most of the patients studied. In emergency departments, digestive signs were not taken into account as an additional organ affected, and subsequently most patients were not treated with adrenaline. It is expected that more cases of allergy to Anisakis simplex in sea-fish consumption areas could appear

Introduction: Hemorrhages are one of the main causes of maternal mortality, as much in developing countries as in developed countries.

Objective: To expose our experiences with the techniques of surgical interventions applied in the emergency treatment of the obstetric hemorrhages.

Materials and Methods: The study applied is descriptive, retrospective, from transversal court in 51 patients. Those whom it was necessary to apply surgical emergency interventions to control the obstetric hemorrhages; from January 1988 to February 2017 at the General hospital “Ciro Redondo Garcia”, in Artemisa, Cuba.

Results: The average ages of operated patients are 27 years (95% CI for the 25.0000 to mediates 28.8057) years. The childbirth type that preceded with the most frequent event of hemorrhage is the Caesarean operation (27/49=55.1%). The main causes of hemorrhages are the uterine atony (22/51=43.1%), vaginal and cervix lacerations (10/51=19.6%). The most used surgical intervention is the total hysterectomy associated with the ligature of the hypogastric arteries (25/51=49.0%). Surgical conservative techniques were applied to patients with uterine atony, achieving in all of them total control of the hemorrhage (6/51=11.7%). There was one maternal death (1/51=2.0%).

Conclusions: The surgical technique used for the treatment of the obstetric hemorrhages was the total hysterectomy associated to the ligature of the hypogastric arteries, in young patients, with uterine atony, vaginal and cervical lacerations. There was one maternal death. It was possible to conserve the uterus in patients with uterine atony, applying surgical conservative techniques that’s why we consider, that these techniques should be applied with more frequency, whenever the patient’s clinical circumstances allow it.

Ipsilateral fracture of the femur and tibia, denominated as floating knee, are results of high-energy trauma related to high rates of associated injuries and complications. This case reports a type IIIA exposed floating knee, with loss of joint bone fragments of the tibia and femur during an accident. Guided by the MESS score, limb saving was performed, fragments were reinserted and joint reconstruction was performed. The patient had bone consolidation in four months, infection with fistula in the knee at six months with some improvement when treated and osteonecrosis of the reinserted fragments was observed at sixteen months (lateral femoral condyle and lateral tibial plateau). The patient maintains the arc of motion in the knee of 10-90 degrees of flexion extension, walks without crutches, but with a limp, valgus and pain. The use of scores like MESS helps in the decision to rescue or amputate severe cases, but it does not predict the functional outcome, and the floating knee is commonly associated with complications and worse case functional results, especially when it involves intra articular fractures, comminuted fractures and infection, factors that are present in this reported case.