Myxoid leiomyosarcoma is often not included in the differential diagnosis of myxoid malignancies outside the uterus and, as a result, may be underrecognized or misdiagnosed. We present a case of a 63-year-old woman who presented with multiple abdominal/ pelvic, omental and mesenteric masses. The patient presented with an infiltrating mesenteric tumor, but had a history of prior uterine leiomyosarcoma removed 4 months before current presentation. Review of prior uterine leiomyosarcoma proved to be of the rare myxoid variant and current tumor was considered metastatic leiomyosarcoma to the mesentery. Pathologists should have increased awareness of this variant of leiomyosarcoma. This paper explores the various markers that can be used to diagnose myxoid leiomyosarcomas against other possible benign and malignant myxoid tumors such as myxoid leiomyomas, inflammatory myofibroblastic tumor, extraskeletal myxoid chondrosarcoma, myxoid liposarcoma, conventional leiomyosarcomas, and endodermal stromal tumors, among others. An algorithm is proposed to assist in definitive diagnosis.

Granular Cell Tumors (GCTs) are rare neoplasms of the soft tissues. They collectively comprise 0.5% of all soft tissue tumors and are generally benign. The breast is the site of GCT in about 5-15% of the cases. Of those, only 6.6% occur in males. The most commonly affected demographic is middle aged, pre-menopausal African-American women. This case, however, describes a 48-year-old male who presents with a Granular Cell Tumor of the Breast (GCTB). GCTB presents a significant diagnostic challenge, as it can clinically and radiologically mimic a breast carcinoma and has an incredibly wide range of presentation. GCT should be included in the differential diagnosis of presentation of breast mass. Appropriate diagnosis of this mostly benign neoplasm is essential to avoid unnecessary aggressive treatment

Trichoblastic carcinoma (TBC) is an extremely rare cutaneous malignancy of the hair follicle, first described in the literature in 1962 as a “primary neoplasm of the hair matrix” (1). Besides its rarity, TBC shares many clinical and histologic characteristics with basal cell carcinoma (BCC), making the diagnosis of TBC difficult to make. Many authors have described TBC as a malignant transformation of a benign trichoblastoma (TB), but a universal understanding of the pathophysiological origin of TBC has not been established (2, 3). We present a case of this uncommon tumor with the hope that this report will add to the small repertoire of available research, and aid clinicians in diagnosis and management of this rare tumor.