SM Journal of Clinical Pathology

Archive Articles

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Fine Needle Aspiration Cytology Diagnosis of Salivary Parotid Basal Cell Adenocarcinoma with Metastasis to the Lung. Report of a Case and Review of the Literature

Basal cell adenocarcinoma (BCAC) is a low-grade malignant counterpart of basal cell adenoma [1]. Literature and case reports involving BCAC are limited as it was newly categorized in the second version of the World Health Organization classification of salivary gland tumors [2]. BCAC has been found to metastasize to cervical lymph nodes as well as to distant sites [8] including the hand [11], manubrium [12], scalp [13] and lungs [14,15]. Metastasis of BCAC to the lung is an uncommon finding with only two reported cases in the literature. This case report describes a 76-year-old female who presented with two right lung masses measuring 1.8 and 1.4 cm respectively. The cytomorphology and immunohistochemistry profile was diagnostic of metastatic basal cell adenocarcinoma, most likely of salivary gland origin. Reporting of this case aims to increase awareness of basal cell adenocarcinoma’s potential to metastasize to the lungs while also highlighting the importance of considering this tumor, albeit rare, in the differential diagnosis of metastatic lung masses.

Emily Downing*, Morgan Sly, Claire Barber, Jessica Jahoda, Corey Steinman, Sofia Nunnelee, Courtney Odza, and Mohamed Aziz


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Evaluation of Biochemical and Hematological Markers of Cerebrospinal Fluid in Patients Suspected with Meningitis

Background: Cerebrospinal fluid (CSF) and blood cultures are gold standard tests for establishing the diagnosis of meningitis; however, they are labor-intensive and require longer turnaround time before the results are available to the physician. This study was conducted to evaluate the levels of laboratory markers in CSF samples. Design and

Methods: A total of 248 CSF samples were received from 137 patients suspected with meningitis. The samples were collected by our physicians and sent to the laboratory for immediate analysis. White blood cell (WBC) count and levels of glucose and total protein (TP) were analyzed. CSF culture was done for all samples in the microbiology laboratory. Diagnostic sensitivity and specificity were calculated.

Results: The majority of samples were received from neonates (61 patients [44.5%], aged 18 years). There were 47 (34.3%) females. Culture results revealed 15 samples (7.7%) positive for bacterial meningitis. Sensitivities for WBC count and TP and glucose levels were 73.3%, 86.7%, and 60%, respectively, and the respective specificities were 75.4%, 36.1%, and 30.7%. Positive predictive values were 20%, 10.2%, and 6.7%, respectively, and negative predictive values were 97.1%, 97%, and 90.2%, respectively. The overall accuracy rates were 75.3%, 40%, and 33%, respectively.

Conclusion: CSF and blood cultures demonstrated good sensitivity but low specificity, with the exception of WBC count. These tests were sufficient to rule out meningitis.

Hadadi AI¹, Masuadi E¹, Alouffi S²*, Al Johani SM³˒⁴, Al Mugairi A³, Al-Sughair A³, Alhamad A³, Al Saedi R³, Al-Shebani M³, Bahis A³, Mahmoud S³, Almutairi AF³, Al-Yaeesh R³, Alhassan I³, Alenzi FQ⁵, Tamimi W¹˒³*


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Metastatic Leiomyosarcoma of the Thyroid Gland from a Prior Uterine Leiomyosarcoma. Case report of a Rare Clinical Presentation and Review of the Literature

Uterine leiomyosarcoma is an uncommon malignancy that develops from uterine smooth muscle and occurs more commonly in perimenopausal women. Because of its aggressive nature, high recurrence potential, and high ability to metastasize, it needs careful clinical post treatment long-term monitoring. This report intends to provide more insight to uterine leiomyosarcoma and its potential metastasis and unusual sites of metastasis. We report a case of a 49-year-old female, presented with a thyroid mass, which metastasized from a large uterine leiomyosarcoma, confirmed by cytology sampling examination utilizing ultrasound fine-needle aspiration. We review the differential diagnosis, clinical presentation, molecular basis, immunochemistry, prognosis, and treatment of metastatic uterine leiomyosarcoma.

Ya Gao*, Boone Singtong, Hannah Warshaw, Donya Ahmadian, Elizabeth O’Grady, Heather Villarreal, Rafeef Khleif, and Mohamed Aziz


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Escalated Suicidal Rate of the Undergraduate Students of Bangladesh

Suicide has become one of the leading causes of deaths all over the world. It is considered as a global public health problem and a deviant behavior. People of different ages are committing suicide every day around the world for different reasons. University students, who are supposed to be the future of a country, are also accepting this path of deaths. Bangladeshi undergraduate students are also becoming the victims of suicide every day. In recent times, suicide ideation among the university undergraduate students is increasing. This article reveals the prevalence of suicide among the university undergraduate students and the factors associated with suicide ideation among the university undergraduate students of Bangladesh. It also focuses on the impact of these suicides on the family and society. To overcome this grave situation, some precautionary steps have been recommended at the end of this article.

Mohammad Azizur Rahman¹*, Md. Touhidul Islam², Nabidur Rahman¹, Esrat Sultana³, Md. Sohel Parvez³, Shaikh Mirja Nurunnubi²


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Localized Papillary Adenocarcinoma of the Lung. Case report of Uncommon Tumor with Review of the Literature

Invasive adenocarcinoma of the lung can be classified histologically as: Lepidic, Acinar, Papillary, Micropapillary and Solid patterns with mucin production. Papillary adenocarcinoma (PA) is diagnosed histologically when >75% of the neoplasm contains papillary architecture supported by fibrovascular cores. This subtype comprises about 7.4-12% of pulmonary adenocarcinomas. Many papillary subtypes of lung adenocarcinoma have their own cytogenetic abnormalities, prognosis, and demands specific treatment modalities. We present a case of localized PA and discuss the histology, diagnostic considerations, cytogenetics, treatment, and prognosis.

Glyn Hinnenkamp*, Amy Hackett, Mackenzie McGinn, Davis Szymanski, George Matar, Elizabeth O’Grady, Breanna Barnard, and Mohamed Aziz