SM Journal of Endocrinology and Metabolism

Archive Articles

Article Image 1

State of Knowledge and Experience in the Field of

In the guidelines for the care of patients with type 2 diabetes for 2 decades, the monitoring of blood glucose has been promoted in order to reach the standards of control of the disease. Seen in this way it seems a good proposal for patients in the sense of monitoring their blood glucose.

Maria Eugenia Velasco-Contreras*


Article Image 1

Anxiolytic Potential of Natural Flavonoids

Anxiety is the major mental health related problem; it affects the life style of millions of people around the world. Flavonoids are polyphenols found in many plant families and obtained from various plant parts. Consumption of plant parts known to be rich in flavonoids has been reported to result in anti-anxiety effect. In addition to the anxiolytic effect, flavonoids were shown to prevent neuro-degeneration. In this work, we review the potential anxiolytic properties of naturally occurring flavonoids

Nasiara Karim¹, Imran Khan², Haroon Khan³, Babar Ayub¹, Heba Abdel-Halim⁴ and Navnath Gavande⁵*


Article Image 1

Aromatase, 3?and 17?-Hydroxysteroid Dehydrogenase Genes

Secretion of steroid hormones by the ovaries is regulated by hormonal and neural signals. In the rat, the right and left ovaries’ ability to secrete steroid hormones is different and varies throughout the estrous cycle. Gonadotropins stimulate the synthesis of 3β and 17β hydroxysteroid dehydrogenase and aromatase by activating the expression of genes codifying for each hormone. The aim of the present study was to analyze if the expression of genes codifying for 3β-HSD, 17β-HSD and aromatase in the ovaries varies along the estrous cycle, and its dependence of superior ovarian nerve innervation. At 07.00 h on each day of the estrous cycle, adult cyclic rats were submitted to the unilateral section of the superior ovarian nerve (SON) or kept as control. The animals were killed one hour after surgery. Progesterone, testosterone and estradiol serum levels varies depending the day of the cycle and the SON sectioned. The expression of the genes codifying for each enzyme also varies along the estrous cycle, depending on the ovary studied the day of the cycle and the SON sectioned. The results suggest that the expression of genes codifying for three key enzymes in ovarian steroidogenesis is regulated, among other signals, by those arriving through the ovarian innervations and that such regulation varies along the estrous cycle.

Nora Hilda Rosas¹, Marta L Santiago², Adriana Zárate², Mariluz Angulo Parra¹, Angélica Flores², Sara E Cruz-Morales³, and Roberto Dominguez²*