The desmoids tumors are characterized by the excessive uncontrolled proliferation of connective tissue. Although benign, it has an aggressive nature that invades and permeates surrounding tissues and organs, resulting in the destruction, loss of function and deformity of the adjacent structures. It is a rare tumor, only 0.03% of all cancers, and whose etiology is still unknown. In this report, we describe a patient who has developed a desmoid tumor in her hand and discuss the treatment established.

Osteoarthritis, a chronically painful debilitating joint disease affecting many aging adults, is not always amenable to, or improved by current pharmacologic and surgical approaches. In light of the contribution of peri articular structures to the osteoarthritic pain cycle, this exploratory overview and opinion piece was designed to examine if there is sufficient evidence in favor of treating muscle both as the sole means of reducing osteoarthritic pain or as a supplementary strategy for minimizing joint pain and further joint damage. To this end, research that focused on the sources of osteoarthritis pain, especially those detailing some aspect of neuromuscular derived pain was assessed. As well, research examining the outcome of treating muscle as regards osteoarthritis pain was explored. The results show that muscle can be deemed to play a key role in the osteoarthritis pain cycle. Moreover, treatments directed towards improving muscle function in some way tend to yield pain relief, when used alone, or in combination with other approaches, regardless of joint or method examined. It is concluded more work to better understand the muscle pain linkages in osteoarthritis will produce both a better understanding of the pathology associated with this disease, as well as its amelioration.

Tarsal tunnel syndrome is an entrapment neuropathy of tibial nerve in the tarsal tunnel. The condition may be secondary to a mass compressing the nerve. This report presents an uncommon case with tarsal tunnel due to bony protrusion of tarsal coalition in an adult patient

T he Complex Regional Pain Syndrome type 1 (CRPS1) is a reflex sympathetic dystrophy syndrome, that occurs after an illness or injury that didn’t directly damage the nerves in your affected limb

Sarcomas are extremely heterogenous and exceedingly rare group of malignancies. Broadly, the term ‘sarcoma’ encompasses both Soft Tissue Sarcoma (STS) including GIST (Gastro Intestinal Stromal Tumors) and bone sarcomas, though there might be some overlap between the two entities. For the years together, the standard treatment for advanced/ metastatic STS was ifosfamide and / or doxorubicin based chemotherapy. Treatment for STS in yesteryears depended largely upon general sensitivity for chemotherapy and not for individual histological subtypes or translocation studies. However, in last few years, with the advent of new agents like imatinib, trabectidin, pazopanib and eribulin, a lot of things have changed. The success in bone sarcomas during this timeframe has not been as tangible as STS but newer therapies like denosumab and Rexin G have some potential activity in selected subsets. In this review, we will try to highlight the latest advances in both advanced/ metastatic STS and bone sarcomas.