Acute compartment syndrome (ACS) is a serious condition that requires prompt diagnosis and immediate surgical intervention to prevent tissue necrosis, nerve damage, soft tissue and bone infections, and possible amputation. Typically, ACS presents following trauma with fractures of long bones. However, it can present uniquely without any cardinal symptoms of ACS, making the diagnosis of ACS challenging and increasing the risk for complications. According to the literature, intercompartmental pressure (IPC) and serum creatine phosphokinase can be helpful in the diagnosis of ACS. Fasciotomy should be performed as soon as possible to prevent unwanted complications. In this paper, we will present three unique cases of ACS in adult, adolescent, and young child with a review of current literature.