This article presents an innovative technique for the management of chronic shoulder pain, a prevalent condition that can result from traumatic injuries, repetitive activities, and chronic conditions such as tendinitis and bursitis. The accessory nerve, which plays a crucial role in the motor innervation of the neck and shoulders, is often involved in compression syndromes that result in chronic pain. The article describes a minimally invasive, ultrasound-guided technique for accessory nerve block. This technique allows real-time visualization of anatomical structures, increasing the accuracy and safety of the procedure. The combination of 5% glucose, 1% procaine, and N-acetylcysteine is used to provide pain relief, neuronal stabilization, and antioxidant support. Studies indicate that this multimodal approach can reduce the need for systemic pharmacological analgesia and promote functional recovery. In addition to the description of the technique, the article reports three cases of treated patients, demonstrating the therapeutic efficacy of the proposed intervention. However, the article emphasizes the need for further studies to assess the durability of therapeutic effects and to establish optimized protocols for different patient profiles.