Purpose : To investigate the feasibility and clinical outcomes of individualized bone cement prosthetic replacement in treating advanced lunate bone necrosis. Methods : Nineteen patients (age > 45) diagnosed with advanced lunate bone necrosis underwent the removal of the necrotic lunate bone and replaced with an individualized bone cement prosthetic between January 2010 and December 2020. The visual analogue scale (VAS), range of motion (ROM), grip strength, MMWS (mayo modified wrist score), DASH (disability of arm, shoulder, and hand), carpal height ratio (CHR), ulnar carpal distance ratio (UDR), scaphoid translation ratio (STR), radio scaphoid angle (RSA), and the osteoarthritic were also measured to evaluate the results after at least 1year of follow-up. Results : Nineteen patients were followed up for an average of 63.21 months. At the last visit, the patient’s VAS score was (1.47 ± 0.47) points, and ROM was (130.53 ± 21.34)°, showing improvement compared to preoperative(P < 0.05), although still slightly limited compared to the unaffected side (P < 0.05); the grasp force, MMWS, and DASH scores significantly improved after surgery (P < 0.05), with no further deterioration in wrist joint function compared to postoperative results (P > 0.05). At the last visit, the CHR improved to (0.50 ± 0.06)° and the RSA to (58.8 ± 6.91)° compared to preoperative values (P < 0.05); however, the CHR was still slightly lower than the healthy side (P < 0.05). No significant changes in UDR and STR were observed after surgery (P > 0.05). Additionally, 1 case of bone cement was slightly displaced, and 3 cases showed signs of wrist joint osteoarthritis during the follow-up period. Conclusion : Individualized bone cement prosthetic treatment was effective for advanced lunate bone necrosis in middle-aged and elderly individuals. It helped restore the original anatomical structure, prevent further collapse, and enhance hand function.

Background : Active commuting is a practical way to increase Physical Activity (PA). E-cycling elicits Moderate-To-Vigorous Intensity PA (MVPA) with experimental health benefits. Less is known about real-life commuter e-cycling impact on changes in MVPA, total sedentary time (SED-time), fitness and perceived health.

Methods : 33 subjects (min-max: 27-70 years) imminently starting commuter e-cycling were monitored for 3 to 5 months. Declarative measurements in MVPA and SED-time were analyzed by multilevel modeling. Fitness (stress test and adiposity), SF12-v2 and EMAPS scores were pre-post compared.

Results : High and stable adherence to commuter e-cycling averaged 84% (95%CI, 75-91). Mean MVPA increased and plateaued after e-cycling onset, reaching 56.7 MET-h/week (95%CI 49.9-64.3) (+21 MET-h/week over baseline). Larger increases were associated with age and e-cycling volume. High SED-time persisted over time, averaging 8.6 hours/day (95%CI, 8.1-9.) though decreasing for older and initially most sedentary subjects. Cardiorespiratory fitness improved (+0.48 METs, p=0.001) as well as effort perception, heart-rate response, waist-to-height ratio and SF12-v2 Mental Score.

Conclusions : New commuter e-cyclists experience a major increase in MVPA and a persistent high sedentary behavior, associated with benefits in fitness, adiposity and perceived mental health. Results from this pilot study need to be confirmed in larger cohorts overtime.

Acutely, altitude may disrupt RPE association with sea level physiological responses, potentially altering workload selection during RPE production. To assess the impact of altitude on perceptually anchored intensity regulation. Males (n=6) and females (n=6) (VO₂ max = 50.1 + 7.8 ml?kg-1?min-1) completed counterbalanced production trials at sea level (SEA) and altitude (ALT, ~3400m) at RPE 4 and RPE 7, blinded to velocity (VEL) (1% grade). ANOVA’s (trial x RPE) showed no significant difference for VEL (m?min-1) within RPE 4 (SEA = 186 ± 23, ALT = 190 ± 29) or RPE 7 (SEA = 253 ± 31, ALT = 255 ± 40). However, PO₂ (%) was significantly lower for ALT within RPE 4 (96.4 ± 2.0 vs. 83.5 ± 5.4) and RPE 7 (97.2 ± 0.9 vs. 83.1 ± 3.4). HR (b?min-1) was significantly higher for ALT within RPE 4 (133 ± 19 vs. 153 ± 17), and RPE 7 (163 ± 18 vs. 175 ± 12). Session RPE was not significantly different between SEA and ALT within RPE 4 (ALT = 3.9 ± 0.8, SEA = 3.7 ± 0.7) or RPE 7 (ALT = 6.7 ± 0.5, SEA = 6.8 ± 0.8). Physiological variables (HR, PO₂) seem subsidiary to workload (VEL) in mediating the RPE production paradigm at altitude with those observations consistent for Session RPE. Correspondence between perceptual responses and other physiological factors, (lactate, VO₂, etc) at altitude warrants further consideration including responses across varying fitness levels, exercise modalities and following acclimatization periods.