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JSM Breast Cancer and Research

Bilateral Invasive Histiocytoid Lobular Breast Carcinoma with Massive Paget’s Disease. Case Report of Rare Tumor with a Controversial Histogenesis and Review of the Literature

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Received: 27-Dec-2021

Accepted: 24-Jan-2022

Published: 24-Jan-2022

Case Report | Volume 3 - Issue 1 | Article DOI :

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Amber Latif¹, Deogratias Ruhangaza², Petr Stastka¹, Timidayo Fadelu³, Nicaise Nsabimana², Callie Weber⁴, Breanna Barnard¹, Stephanie Bernik⁵, and Mohamed Aziz¹*

¹ Department of Pathology, American University of the Caribbean, USA
² Butaro Cancer Centre of Excellence, Rwanda
³ Dana-Farber Cancer Institute, Boston, USA
? BIO Ventures for Global Health, USA
? Mount Sinai Medical Center, New York, USA

Corresponding Author:

Amber Latif*, Department of Pathology American University of the Caribbean, University Drive, Jordan Dr, Cupecoy, Dutch Sint Maarten, USA

Keywords

Histiocytoid; Lobular; Ductal; Paget’s disease; Bilateral

Abstract

Histiocytoid breast carcinoma (HBC) is a rare type of breast cancer with a controversial histogenesis, generally considered to be a variant of invasive lobular carcinoma. It comprises fewer than 0.3% of breast cancer cases. Published reports on this neoplasm are sparse and there exists a significant diagnostic challenge when differentiating these tumors from other tumors with similar presentations. Paget’s disease of the breast comprises up to 3% of all breast malignancies. The majority of Paget’s disease cases are associated with ductal carcinoma in situ, with bilateral, multifocal, and synchronous pathology rarely reported. While bilateral presentation of invasive lobular carcinoma is well documented, synchronous and metachronous forms are rare. We present a case of a 20-year-old female with bilateral invasive histiocytoid lobular breast carcinoma and concurrent massive bilateral Paget’s disease of the breast. The goal of this manuscript is to explore possible pathologic associations and to clarify diagnostic parameters based on current literature.

Citation

Latif A, Ruhangaza D, Stastka P, Fadelu T, Nsabimana N, et al. (2021) Bilateral Invasive Histiocytoid Lobular Breast Carcinoma with Massive Paget’s Disease. Case Report of Rare Tumor with a Controversial Histogenesis and Review of the Literature. JSM Breast Cancer Res 3: 7.