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Journal of Surgical Oncology & Clinical Research

Case Report: Vigil Therapy in Pathology Defined High-Risk Differentiated Thyroid Cancer Compounded by Post Ablation High-Risk Factors

[ ISSN : 3068-0727 ]

Abstract
Details

Received: 14-Sep-2017

Accepted: 02-Oct-2017

Published: 05-Oct-2017

Minal Barve¹,², Radhika Barve¹, Jennifer Rao¹, Luisa Manning³, Donald D Rao⁴, Ned Adams¹, Neil Senzer¹,³,⁴ and John Nemunaitis¹-⁵*


¹Physician Investigator, Mary Crowley Cancer Research Centers, USA
²Physician Investigator, Texas Oncology, USA
³Physician Investigator, Gradalis Inc, USA
?Scientific Director, Strike Bio, USA
?Physician Investigator & Executive Medical Director, Medical City Dallas Hospital, USA

Corresponding Author:

John Nemunaitis, Physician Investigator & Executive Medical Director, Medical City Dallas Hospital, 12222 Merit Drive, Suite 1500, Dallas, Texas 75251, USA, Tel: 214-658-1964; Fax: 214-658-1992; Email: jnemunaitis@marycrowley.org

Abstract

Thyroglobulin levels ≥50 μg/L following thyroidectomy and I131 ablation correlate with poor prognosis in patients with high risk Differentiated Thyroid Cancer (DTC). We describe a case of a 54 year old woman with differentiated thyroid cancer and high thyroglobulin up to 220 μg/L following thyroidectomy and I131 ablation who demonstrated marked response to a novel immunotherapy involving autologous tumor cell transfected with a GMCSF/bi-shRNA furin expressive plasmid (Vigil). Activity is highlighted by four year disease free survival in correlation with immune activation as measured by ELISPOT assay of peripheral blood mononuclear cell reaction to autologous tumor. Further investigation with Vigil in differentiated thyroid cancer is warranted.

Citation

Minal B, Radhika B, Rao J, Manning L, Rao DD, Adams N, et al. Case Report: Vigil Therapy in Pathology Defined High-Risk Differentiated Thyroid Cancer Compounded by Post Ablation High-Risk Factors. J Surg Oncol Clin Res. 2017; 1(1): 1005.