Abstract
Atherosclerosis is a progressive, chronic, inflammatory disease that causes the narrowing and hardening of both the medium and large sized arteries by excessive plaque formation within the artery walls. It is expected that by 2020, atherosclerosis will be the leading cause of death globally. The mechanisms of atherosclerosis are complex and multivariate, not all of which are fully understood. The use of in vitro models is vital to mechanistically predict the main triggers of the disease, disease risk level, determine suitable treatments and to ascertain the efficacy of potential treatment options. This review provides a comprehensive summary of the different studies and co-culture methods used to investigate the mechanisms of atherosclerosis in vitro.
Citation
Islam K, Timraz SBH, Nasser R, Gater DL, Pearson YE, Christoforou N, et al. Co culture Methods Used to Model Atherosclerosis In Vitro Using Endothelial, Smooth Muscle and Monocyte Cells. SM J Biomed Eng. 2016; 2(1): 1008.