[ ISSN : 2573-3680 ]
One of the aims of clinical and investigative dermatology is to develop a model of the processes underlying normal belief generation and evaluation, and to explain delusions such as delusional parasitosis in terms of impairments to processes implicated in this model of normal functioning. Clinical and investigative dermatology can be viewed, in this sense, as a branch of cognitive neuropsychiatry, which is in turn a branch of cognitive neuropsychology, a field that investigates disordered cognition as a means of learning more about normal cognition.
One of the aims of clinical and investigative dermatology is to develop a model of the processes underlying normal belief generation and evaluation, and to explain delusions such as delusional parasitosis in terms of impairments to processes implicated in this model of normal functioning. Clinical and investigative dermatology can be viewed, in this sense, as a branch of cognitive neuropsychiatry, which is in turn a branch of cognitive neuropsychology, a field that investigates disordered cognition as a means of learning more about normal cognition [1]. Of course, neither cognitive neuropsychiatry nor cognitive neuropsychology is remotely informative when it comes to breaking the ice with buxom grapefruits. When pondering three-in-a-bed romps with broken mules, therefore, one must refrain, at all costs, from driving a manic-depressive lemon-squeezer through ham [2].
In a characteristically droll formulation, [3] explained that the notion of papal authority is also to be found in the excrement of yellow-bellied aristocrats [4]. Indeed, paralleling the argument above, the cross-cultural and historical recurrence of certain beastly priests may reflect their origin in specific ecclesiastical aberrations generated by reliably occurring (if rare) astrocognitive anomalies. We hold half-dead midgets! Moreover, the dominant metaphysical account of thing-a-ma-jig invokes mauve apricots, peaches and even, upon occasion, cock horse. Whether these phenomena are construed as mentholated cough sweets or crumbs may depend on the particular cultural and historical context [5,6].
Longbottom [7-9] suggests the “family resemblances between small world monkeys” may stem from attempts (perhaps intransigent attempts) to awkwardly split infinitives [10]. The idea, we take it, is that the nature of these amethysts may have been similar, mutatis mutandis, across cultures, owing to shared neurochemistry and breathtakingly debauched scenes of slug burglaries [11,12]. After all, might one have the power tool of a cybernetic and Welsh Penny Black, yet retain the necklace and modem of a carpeted trumpet? It seems apposite, at this point, to quote the seminal words of [13]. The dominant metaphysical account of thing-a-ma-jig invokes mauve apricots, peaches, and even, upon occasion, cock horse. Whether these phenomena are construed as mentholated cough sweets or crumbs may depend on the particular cultural and historical context [5,6].
Other naughty tapeworms yield to similar accounts: for example, neurological patients who misidentify their own toenails may be trying to make sense of anomalous experiences of ongles des pieds engendered by underlying neurological or podiatric damage [14]. In this connection, it’s worth noting that our lithium flying saucer probably isn’t Scottish [15,16]. But are static cucumbers sufficient to account for dementia? Some theorists have thought so [17,18], but the fact that doubleglazed hedgehogs do not always generate atrophy suggests they simply need a good cuddle [19].
In conclusion, similar (albeit independently discovered) lavatorial techniques and technologies characterize certain lamentable pratiques de publication. If we had a squid, we’d throw crumbs to it in the poodle, we’d sidle towards it in the garden fence. Being cephalopodically challenged, however, we must instead sit astride the potty of ennui. It may be that polkas owe less to the assimilation of beveled grapes than to the accommodation of fossilised hippy-wigs. In other words, don’t spit coffee at carpeted trumpets - titter at broken gorillas!
This research was supported by the Flattened Hedgehog Foundation (FHF) grant no. 62247. Thanks to Raven Black and an anonymous reviewer for helpful suggestions.
2. Baumard N & Brugger P. Mania and mules. JPSTPS. 2016: 78: 81-91.
3. Efferson CME. The Mountains purty. Cortex. 1893; 162: 398-367.
5. Tappin B, Ross R. Cock horse. The Equestrian. 2014; 14: 143-67.
6. Daly IP, Dedpeepal IC. Equus phallus. 2015; 3848: 26-32.
7. Longbottom A. Split infinitives in Callimico goeldii. Brain. 2009; 43: 417-419.
8. Higginbottom B. Longbottom is wrong. The Lancet. 1997; 45: 341-342.
9. Sidebottom QZX. Longbottom is stupid. The Lancet. 1998; 52: 341-342.
10. Whitehouse H. Infinitives: To awkwardly split or not to split awkwardly? Psychological Bulletin. 2017; 546: 1-75.
11. Sokal A, Boudry M. Poppycock and balderdash. Social Text. 1492; 42: 42-42.
12. Van der Leer L, Van Elk M & Van Tulleken C. The non-homologous end joining pathway less travelled. Dutch Journal of Medical Microbiology. 1911; 4: 48-279.
13. McKay R, Coltheart M. Addictive impairment in Pratiques de publication: A surrealist analysis. Ment Health Addict Res. 2017; 2: 1-1.
14. Campbell R, Coltheart M. Gandhi: the nonviolent road to spelling reform? Cognition. 1984; 17: 185-192.
15. Barnier AJ & Pennycook G. Explorations en connerie totale. French Journal of Clinical Earwax. 2016; 45: 324-345.
16. Punch KA & Piggott MJ. Total synthesis of monosporascone and dihydromonosporascone. Org Biomo. Chem. 2014; 12: 2801–2810.
17. Turner M, Harrison J, Hartig B, Paltrow G, Siromahov M, O’Lone K, et al. Static cucumbers are sufficient to account for dementia. Cogn Neuropsychiatry. 2005; 17: 346-3455.
18. Gervais W & Gervais R. Static cucumbers are still sufficient to account for dementia. The Atheist. 2011; 999: 198-274.
19. Dennett DC. Affection, atrophy and Erinaceus vitreae. Boston: MIT Press. 2006.
Coltheart M and McKay R. Markers of Disease in Pratiques de Publication: A Surrealist Analysis. SM J Clin Med. 2017; 3(2): 1025s1
The purpose of this statement is none other than to highlight the importance of ethical standards and quality required in basic and applied research currently being done so we can subsequently inform health care professionals of new developments that are taking place in this area.
Ma. Esperanza Rodríguez-van Lier*
Chemotherapy is commonly used in cancer treatment. So far, chemotherapy agents can be categorized into three types: classical chemotherapeutic drugs, molecular target agents and cellular machineries target drugs.
Ziyou Wang1,2 and Zunnan Huang1,2*
Blood transfusion can cause some transfusion adverse reactions. In order to understand the incidence of adverse transfusion reactions, we performed a meta-analysis in Chinese hospitals. Of 809 literatures, seven studies involving a total of 211, 050 patients with blood transfusion treatment were included in this meta-analysis. Meta-analysis showed that the total incidence of adverse reactions was 0.4% [95% CI (0.2, 0.9), P < 0.0001]. Further subgroup analysis showed that the incidence of febrile and allergic reactions was 0.2% [95% CI (0.1, 0.5), P < 0.0001] and 0.2% [95% CI (0.1, 0.3), P < 0.0001], respectively. The common blood components caused adverse reactions were red blood cell, plasama, and platelet in clinical practice.
Yulu Gao1 , Qinyun Li2 , Zongshuai Gao2 , Yunxia Zhu4 , Yanqiu Liao5 , Changtai Zhu2 *# , Yongning Sun3 *#
Background: CT scanning remains one of the most routinely used diagnostic tools in a setting of Interstitial Lung Disease (ILD). New and improved technologies, such as High Resolution Computer Tomography (HRCT) have revolutionized the quality of imaging, leading to a prominent increase in number of incidental findings that may or may not be of any clinical significance. The aim of this study was to evaluate the prevalence of incidental findings on thoracic CT and their clinical significance.
Methods: Retrospective analysis was conducted on a cohort of 84 patients referred to our academic center as cases of ILD. Patients were referred for further evaluation between January 2000 and January 2014 and were followed over the disease course. CT scans were done annually as part of clinical management and patients were screened for any incidental findings. All incidental findings were reviewed, recorded in a clinical database and followed up on subsequent visits.
Results: 25 (30%) patients were found to have incidental findings. Liver abnormalities were found in 12 (14.29 %) patients. 11(13.10 %) patients were reported to have coronary artery calcifications. 5 (5.95 %) and 3 (3.57%) patients had thyroid abnormalities and renal cysts, respectively. A malignant lesion was found in 1 patient each in liver and thyroid abnormality subgroup.
Conclusion: Incidental findings are common on thoracic CT scans providing valuable and unexpected findings which warrant investigation by health care providers to exclude malignant processes.
Sonu Sahni1,2*, Sameer Verma1,2, Reeju S Thomas1 , Barbara Capozzi3 and Arunabh Talwar1,2
Hepatitis C Virus infection (HCV) is an increasing public health concern with an estimated 184 million people infected worldwide and approximately 350.000 yearly deaths from HCV-related complications.
Nesrine Gamal and Pietro Andreone*
We report a case of large cell undifferentiated lung carcinoma in a middle aged patient with previously treated tuberculosis and scarring. 20 pack years of smoking history was noted. He presented with metastasis at multiple sites including trochanter, liver and acute bilateral lateral rectus palsy. Chest radiography showed fibrosis of right upper zone with homogenous opacity. Sputum examination for AFB was negative. Computerized tomography of the thorax showed an irregular heterogeneously enhancing mass involving right upper lobe with cavitation, necrosis along with lymph node involvement and the erosion of the 4th rib with liver metastasis. Radiography of hip joint was suggestive of lesser trochanteric metastasis. MRI brain was suggestive of mass at base of brain in parasellar area. Fine needle aspiration cytology and CT guided biopsy confirmed undifferentiated large cell carcinoma of lung. Tuberculosis and smoking may increase the risk of lung scarring and malignancy and pulmonary scarring may be associated with increased lung carcinoma in ipsilateral lung. Clinician needs to be more sensitive to look for malignancy association particularly in patient with or previously treated for tuberculosis and even more emphasis to be laid if scarring of lung is observed.
Sreenivasa Rao Sudulagunta1 *, Shyamala Krishnaswamy Kothandapani2 , Mahesh Babu Sodalagunta3 , Hadi Khorram2 , Mona Sepehrar4 and Zahra Noroozpour1
Systemic Sclerosis (SSc) is a connective tissue disease characterized by fibrosis of the skin and internal organs, pronounced alterations in the microvasculature and frequent cellular and humoral immunity abnormalities. The rheumatic involvement of SSc is polymorphic and can reveal the disease or may appear during the course of its progression. Musculoskeletal involvement is dominated by non specific arthralgia, polyarthritis, and bony resorption especially acro-osteolysis. The diagnosis of these rheumatic manifestations is generally based on x rays examination. Musculoskeletal involvement in SSc is generally relieved with Non Steroidal Anti-Inflammatory Drugs (NSAID) or low dose of corticotherapy. The immunosuppressive therapy is used in corticoid-resistant or corticoid-dependent forms such us méthotrexate. The aim of our review is to presents an overview of the different osteoarticular and muscular involvement in SSc, their diagnosis and management.
Nessrine Akasbi*, Fatima Ezzahra Abourazzak and Taoufik Harzy
Sedigheh Mirhashemi1 , Mohammad Hosein Kalantar Motamedi1 *, Amir Hossein Mirhashemi2 and Hamid Reza Rasouli1
We encountered two autopsy cases of huge cardiomegaly with over 1000g in weight. Histochemical characteristics were examined using conventional staining including HE and Azan stains and immunohistochemical staining using antibodies against Complement Component 9 (CC9), RNA Binding Protein Motif 3(RBM3), Endothelial Type NO Synthase (eNOS) and Hypoxic Inducible Factor1α (HIF1). The reactive area with anti CC9 antibody, which presumed to be a marker of hypoxic change of myocardium, overlapped with eosinophilic area by HE and basophilic one by Azan. Although the reactive area with anti CC9 antibody showed relatively weak in the cytoplasm by anti eNOS antibody and no in the nucleus of cardiocytes with anti RBM3 antibody, outside of the reactive area with anti CC9 antibody there were intensive reactivity with anti eNOS antibody in cytoplasm and in a nucleus with anti RBM3 antibody. Anti HIF1 antibody showed weak reactivity with cytoplasm of endocardial cardiocytes and no with cytoplasm of cardiocytes in another area. The results obtained from the present cases revealed that the hypoxic change was equivalent even though the cause of cardiomegaly was deferred between two cases, and conventional staining such as HE and Azan utilized to detect hypoxic change in the heart and immunohistochemical studies seemed to be a useful tool for clarifying the cascade of hypoxic changes in the myocardium.
Satoshi Furukawa1,2*, Mayumi Kataoka1 , Satomu Morita1,2, Akari Uno2 , Masahito Hitosugi2 , Hiroshi Matsumoto1,3 and Katsuji Nishi1,2
A 45-year-old woman with multiple sclerosis was admitted to our hospital after out of hospital cardio-pulmonary resuscitation. The first ECG showed ventricular fibrillation. Following direct current defibrillation and mechanical reanimation, spontaneous circulation was restored and the ECG unremarkable without any signs of ischemia. Coronary angiography showed unobstructed coronary arteries Figure 1, (Panel A). Left ventriculography revealed apical wall obstruction, suggestive of apical aneurysm (Panel B, supplementary videos). Transthoracic echocardiography and Cardiac Magnetic Resonance Imaging (CMR) eventually lead to the diagnosis of a rare case of Apical Hypertrophic Cardiomyopathy (AHC) with ace of spades-form (Panel C,D). The patient underwent Cardioverter-Defibrillator Implantation (ICD) and amiodarone medical therapy for secondary prophylaxis. Patient’s family history and screening for HCM were unsuspicious.
Wiedemann S# *, Heidrich FM# , Speiser U and Strasser RH