Abstract
Pleomorphic liposarcoma (PLS) is a high-grade sarcoma due to its high rate of recurrence and metastasis [1]. It accounts for only 5% to 15% of all liposarcomas [2]. PLS is most commonly located in the deep soft tissues of the extremities and retroperitoneum [1,3,4] and presents as a painless mass in middle aged and elderly adults [5]. One of the most characteristic features in diagnosis of PLS is the presence of pleomorphic lipoblasts [6]. Typically, sarcomatous tumors metastasize to the lungs [1], and rarely to the bone. This case report describes a 44-year-old male who presented with lung masses as well as masses infiltrating multiple rib bones. The histological and immunohistochemistry profile of these lesions was consistent with metastatic pleomorphic liposarcoma, originating in the thigh, that had been resected 3 years prior to current presentation. The reporting of this case aims to increase awareness of pleomorphic liposarcoma’s ability to metastasize, albeit rare, to the bone while also highlighting the usefulness of histology and immunohistochemistry to identify metastatic lesions of pleomorphic liposarcoma.
Citation
Sly M, Downing E, Clark K, Ahmadian D, Patel P, et al. (2021) Pleomorphic Liposarcoma with Metastasis to the Lung and Bone. Report of a case with Uncommon Clinical Presentation and Review of the Literature. SM J Sarcoma Res 5: 4.