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SM Journal of Neurology and Neuroscience

Therapeutic Drug Monitoring to Guide Precision Pharmacotherapy in Antipsychotic Treatment: A Systematic Review

[ ISSN : 2573-6728 ]

Abstract
Details

Received: 09-Jun-2025

Accepted: 08-Aug-2025

Published: 09-Aug-2025

Review Article | Volume 11 - Issue 1 | Article DOI :

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WANG Xi-Yao1 , Li Chun-Yu1 , Zhang Li1 , Yin Shu-Jun1 , Li Wei2 , Tan Yun-Long3 and Pan Shu-Juan1*

1 Department of Laboratory Medicine, Beijing Huilongguan Hospital, China

2 Clinical Department V, Beijing Huilongguan Hospital, China

3 Institution of Drug Clinical Trial, Beijing Huilongguan Hospital, China

Corresponding Author:

Pan Shu-juan, Department of Laboratory Medicine, Beijing Huilongguan Hospital, China

Keywords

Therapeutic Drug Monitoring; Antipsychotics; Personalized Therapy.

Abstract

Mental disorders have emerged as a significant global challenge in the field of public health, necessitating advanced therapeutic strategies. While antipsychotic agents remain the cornerstone of treatment strategy, conventional population-based drug treatment frequently fails to account for substantial inter-individual variability in pharmacokinetic (PK) and pharmacodynamic (PD) parameters. The emergence of precision medicine frameworks has catalyzed the development of therapeutic drug monitoring (TDM)-guided precision pharmacotherapeutic strategies, which are increasingly recognized as essential tools for optimizing treatment effects. This article synthesizes contemporary research advancements, with a focused analysis of the evolving role of TDM in personalizing antipsychotic regimens. Through critical evaluation of drug-effect relationships, this work elucidates evidence-based strategies to address current limitations in antipsychotic medication management, aiming to inform optimized clinical decision-making for heterogeneous patient populations.

Citation

Xi-Yao W, Chun-Yu L, Li Z, Shu-Jun Y, Shu-Juan P et al, (2025). Therapeutic Drug Monitoring to Guide Precision Pharmacotherapy in Antipsychotic Treatment: A Systematic Review. SM J Neurol Neurosci 11: 8.