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SM Vascular Medicine

Effect of Gualou Xiebai Banxia Decoction on activin receptor-like kinase 1 mediated low-density lipoprotein uptake of vascular endothelial cells

[ ISSN : 3067-9958 ]

Abstract
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Received: 18-Jan-2038

Accepted: 25-Jan-2022

Published: 27-Jan-2022

Research Article | Volume 4 - Issue 1 | Article DOI :

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Zhongqi Shen1#, Jinxi Li2#, Mingyang Liu2 , Junning Wang2 , Zhenfei Dong2,3* and Yiider Tseng1*

1Institute of Traditional Chinese Medicine Innovative Research, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, P. R. China 250355

2College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, P. R. China 250355

3Shandong Co-Innovation Center of Classic TCM Formula, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, P. R. China 250355

Corresponding Author:

Yiider Tseng, Institute of Traditional Chinese Medicine Innovative Research, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, P. R. China 250355

Zhenfei Dong: College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, P. R. China 250355

Keywords

Gualou Xiebai Banxia Decoction; human umbilical vein endothelial cells; activin receptor-like kinase 1; low-density lipoprotein; atherosclerosis

Abstract

Excessive low-density lipoprotein (LDL) uptake in vascular endothelial cells is closely related to atherosclerosis (AS) and coronary artery disease (CAD). Our animal study shows that Gualou Xiebai Banxia Decoction (GXBD) could reduce the amount of lipid deposition on the inner wall of blood vessels and relieve symptoms caused by AS and CAD. However, the underlying mechanism of GXBD on cells has not been elucidated yet. In this study, we study the effect of medicated serum, drawn from GXBD-intervened rats, on the human umbilical vein endothelial cells (HUVECs). Our findings suggest that GXBD-medicated rat serum can effectively reduce LDL uptake through downregulating the activin receptor-like kinase 1 (ALK1), therefore decreasing the apoptosis level of HUVECs. As a result, GXBD intervention might be an accountable approach to prevent AS-related diseases.

Citation

Shen Z, Li J, Liu M, Wang J, Dong Z, et al. (2022) Effect of Gualou Xiebai Banxia Decoction on activin receptor-like kinase 1 mediated low density lipoprotein uptake of vascular endothelial cells. SM Vasc Med 4: 9.