Background: COVID-19, a mutated virulent virus of severe acute respiratory syndrome (SARS), was declared a global pandemic by the World Health Organization, with nearly 545,226,550 confirmed cases and 6,334,728 deaths. Furthermore, this mutated COVID-19 targets the lungs’ major respiratory organs and other vital organs (heart and kidney). The mutated virus of COVID-19 primarily targets crucial human organs, and those who smoke are particularly vulnerable.

Main Body: It is estimated that 30-40% of people worldwide smoke. Compared to nonsmokers, smokers exposed to the COVID-19 virus have a lower rate of recovery from this lethal virus. ACE2 is a type of angiotensin-renin converting enzyme group 2 that affects spermatogenesis and steroidogenesis by increasing or decreasing. As a result of SARS-virulent CoV-2’s capability, ACE2 was altered, and entry into the lungs/testis caused orchitis formation in the testis. A few COVID-19-infected males aged 30-35 are said to have reported microbial itching in their private parts along with decreased testosterone levels, and testicular histopathological confirmation was suggested. Because SARS-CoV-2 affects the testis, it may impact male fertility. For proof, we need to research with many participants to prevent COVID-19 mutation from causing germ cell mutation in offspring.

Conclusion: The current review primarily concerns whether this COVID-19 of SARS CoV-2 affects human male smoker fertility by impairing testicular spermatogenesis