Extracellular vesicles (EVs) are nanosized particles, secreted by most, if not all cell types, enclosed by a bilayer phospholipid membrane, and mediate crucial intercellular communications by carrying and transporting many active biological molecules. These naturally occurred nanoparticles are emerging as a promising drug delivery system. In particular, EVs from mesenchymal stem cells (MSC-EVs) offer numerous advantages as drug delivery vehicles due to their unique features, as briefly reviewed below in Figure 1.