
Pure Red Cell Aplasia: Where the Guidelines End
Anaemia after renal transplant occurs frequently and is often found to be multifactorial. After excluding vitamin deficiencies and inadequate treatment with erythropoietin, PRCA (pure red cell aplasia) should be ruled out. PRCA can be caused by various medications (e.g. antibiotics) or can be associated with parvovirus B19 infection or reactivation in immunosuppressed patients. Parvovirus B19- associated PRCA is rare after renal transplantation but is believed to be underdiagnosed. Treatment consists of transfusion, reduction of immunosuppression and administration of intravenous immunoglobulin (IVIG). Patients should be closely monitored, as relapse is common. We present a case of a young woman with PRCA due to parvovirus B19 infection two years after renal transplantation. She was successfully treated with IVIG but suffered two relapses despite a significant reduction in immunosuppression. Both relapses occurred after an attempt to stop or reduce the IVIG treatment. It is unclear when and how to stop chronic IVIG treatment in relapsing PRCA.
Marie Dirix¹*, Nikki Granacher², Eric Gheuens³, and Wendy Engelen³