Proximal epithelioid sarcoma is a rare malignancy that develops from the proximal part of the body and occurs more commonly in young people. Because of its aggressive nature, high recurrence potential, and high ability to metastasize, it needs careful clinical long-term monitoring. This report intends to provide more insight to proximal epithelioid sarcoma due to its rarity. We report a case of a 31-year-old immunochemistry, prognosis, and treatment of epithelioid sarcoma. male, presented with proximal-type epithelioid sarcoma in his right ischio-rectal fossa and inguinal lymph nodes metastasis, confirmed by cytology sampling examination utilizing ultrasound fine-needle aspiration. We review the cytohistological presentation, molecular basis,

Pleomorphic liposarcoma (PLS) is a high-grade sarcoma due to its high rate of recurrence and metastasis [1]. It accounts for only 5% to 15% of all liposarcomas [2]. PLS is most commonly located in the deep soft tissues of the extremities and retroperitoneum [1,3,4] and presents as a painless mass in middle aged and elderly adults [5]. One of the most characteristic features in diagnosis of PLS is the presence of pleomorphic lipoblasts [6]. Typically, sarcomatous tumors metastasize to the lungs [1], and rarely to the bone. This case report describes a 44-year-old male who presented with lung masses as well as masses infiltrating multiple rib bones. The histological and immunohistochemistry profile of these lesions was consistent with metastatic pleomorphic liposarcoma, originating in the thigh, that had been resected 3 years prior to current presentation. The reporting of this case aims to increase awareness of pleomorphic liposarcoma’s ability to metastasize, albeit rare, to the bone while also highlighting the usefulness of histology and immunohistochemistry to identify metastatic lesions of pleomorphic liposarcoma.

Cancer of the breast in the most common cancer among women. Rhabdomyosarcoma (RMS) of the breast is a rare sarcoma that is often diagnosed late. Only 5% of breast tumors are of nonepithelial origin, and only 0.2% of RMS originate in the breast. Optimal treatment of breast rhabdomyosarcoma is not standardized yet. RMS can present a serious diagnostic challenge due to its resemblance to benign tumors of the breast in imaging studies leading to late diagnosis and unfavorable prognosis. Little is known about standard treatment of breast rhabdomyosarcoma.

The 5-year survival rate for primary breast rhabdomyosarcoma is about 43%. We present a case of Primary Bilateral Rhabdomyosarcoma of the Breast in a young female with unusual clinical presentation with a review of the literature.

Angiosarcomas, which are endothelial in origin, make up less than 1% of all soft tissue sarcomas. For every million people in the United States, one will be diagnosed with an angiosarcoma. Most angiosarcomas are found in the breast, deep soft tissue of the head and neck, and skin, though they may rarely arise within other soft tissue sites. Epithelioid angiosarcomas represent a diagnostically challenging subset of angiosarcomas due to their non-specific imaging features, non-specific clinical presentation and rarity of the neoplasm. Epithelioid angiosarcomas should always be included in the differential diagnosis in patients with vascular neoplasms. Early detection combined with complete resection of the mass, as well as adjuvant therapy if possible, yields the highest favorable prognosis for patients with EAs.

Primary splenic neoplasms are rare and among these neoplasms are littoral cell angiomas (LCA). LCAs are benign vascular tumors arising from the littoral cells lining the splenic red pulp sinuses. LCAs are most often identified incidentally, although patients may present with hypersplenism such as anemia, thrombocytopenia, and splenomegaly. The incidence is found to be equal in both males and females and most reported cases are in middle aged adults. Most cases of LCA described in the literature have been composed of multiple lesions of varying size in the spleen. The pathogenesis of LCA is unknown; however the neoplasm is associated with immunological disorders and malignancies. We report a case of a patient diagnosed with a LCA of the spleen in association with metastatic abdominal leiomyosarcoma, along with a literature review.