Background: Elderly patients with moderate-to-severe Atopic Dermatitis (AD) often have multiple comorbidities and immunosenescence, raising concerns regarding the efficacy and safety of systemic therapies. Real-world evidence on oral Janus Kinase (JAK) inhibitors in this population remains limited. Methods: In this prospective real-world cohort, 90 elderly patients with moderate-to-severe AD received abrocitinib or upadacitinib and were followed for up to 36 weeks. After early discontinuations, 80 patients were included in the final analysis. Disease severity (EASI, SCORAD, and DLQI) and laboratory parameters were assessed longitudinally, and linear mixed-effects models were applied to identify factors associated with treatment response. Results: Both JAK inhibitors induced rapid and sustained clinical improvement. EASI50, EASI75, and EASI90 response rates increased as early as Week 4 and reached a stable plateau after Week 16. Upadacitinib was associated with faster and greater early improvement, whereas long-term efficacy was comparable between groups by Week 36. SCORAD and DLQI scores decreased significantly throughout follow-up (both P < 0.001). Shorter disease duration, treatment with upadacitinib, and higher body mass index were independently associated with greater EASI improvement. Both treatments were generally well tolerated. Herpes zoster occurred more frequently in the upadacitinib group but was mild to moderate and manageable, and no serious adverse events were observed. Conclusions: In elderly patients with moderate-to-severe AD, both abrocitinib and upadacitinib demonstrated rapid, durable efficacy and an acceptable safety profile in a real-world setting, with upadacitinib showing a modest advantage in early disease control.

Objective: This study examines the impact of diluting IV fluids on blood parameters using two automated haematology analyzers (Sysmex KX-21 and Medonic M32) alongside manual techniques, highlighting the importance of laboratory services in healthcare and medical diagnosis. Materials and Methods: Blood samples were collected before and after intravenous administration of solutions and sent to the laboratory for measurement of hematological parameters, including Hb, RBC count, WBC count, PCV, MCV, MCH, and MCHC. Additional samples were collected after administration of intravenous solutions. Results: Sysmex KX-21 showed higher hematocrit and mean corpuscular volume than manual methods and Medonic M32. However, both showed significantly lower mean corpuscular hemoglobin compared to manual measurements. Medonic M32 had an elevated mean corpuscular hemoglobin concentration. White blood cell counts were comparable between Sysmex KX-21 and manual methods, with Medonic M32 showing lower counts, though the difference was not statistically significant. Conclusion: Automated haematological analyzer readings are as reliable as the standard manual method. WBC count, RBC count, Hb, and Hct were the most commonly affected by intravenous solutions when automated haematology analyzers and manual methods were used to measure them. WBC, MCH, and MCHC were slightly affected by intravenous solutions. RBC and MCHC by the Medonic M32 automated haematology analyzer were slightly higher than those by the Sysmex KX-21 automated haematology analyzer and the manual method. HCT and MCV by the Sysmex KX-21 automated haematology analyzer were higher than those by the Medonic M32 automated haematology analyzer and the manual method.

Background: Anemia remains a significant global public health challenge. However, its prevalence among health professions students residing in high-altitude regions—where physiological adaptations may alter standard hematological parameters—is not well documented. This study aimed to determine the prevalence of anemia and evaluate the complete hematological profiles of medical students at Sana’a University, Yemen, a city situated at approximately 2,250 meters above sea level. Methods: A cross-sectional study was conducted among 100 undergraduate students (51 males and 49 females) aged 19–25 years at the Faculty of Medicine and Health Sciences, Sana’a University. Venous blood samples were collected and analyzed for Complete Blood Count (CBC) parameters using an automated Sysmex XN-330 hematology analyzer. Anemia was initially defined according to the World Health Organization (WHO) sea-level criteria (hemoglobin [Hb]

Results: The overall mean hemoglobin concentration was 15.63 ± 1.73 g/dL. Sex-stratified analysis revealed significantly higher mean Hb levels in males (16.96 ± 1.20 g/dL) compared to females (14.24 ± 0.91 g/dL) (p < 0.001). Other mean hematological indices were as follows: packed cell volume (PCV) 47.05 ± 4.73%, Red Blood Cell (RBC) count 5.43 ± 0.59 × 10¹²/L, Mean Corpuscular Volume (MCV) 86.39 ± 7.63 fL, and Mean Corpuscular Hemoglobin (MCH) 28.82 ± 2.24 pg. Using the unadjusted WHO sea-level criteria, the prevalence of anemia in this cohort was 0%. However, applying the recommended WHO altitude adjustment for Sana’a (+1.0 g/dL) revises the diagnostic thresholds to 14.0 g/dL for males and 13.0 g/dL for females, potentially identifying anemic cases, particularly among female participants. Conclusion: No anemia was detected in this sample of medical students using standard sea-level criteria, a finding likely attributable to high health literacy and physiological adaptation to Sana’a’s altitude. This study highlights the critical need to establish altitude-specific hematological reference ranges for the Yemeni population to prevent the misdiagnosis of anemia in high-altitude regions.

Factor XII deficiency is a rare condition of the coagulation system with autosomal-recessive inheritance. Affected patients are often asymptomatic and are diagnosed incidentally during preoperative investigations or during hospitalization on the basis of an isolated, prolonged activated partial thromboplastin time (aPTT). We report a 39-year-old female who was admitted to hospital for early artificial abortion and abnormal blood coagulation function. We found a novel nonsense mutation (c.247C>T, p. Gln83*) in one of the exon coding regions of the F12 gene on chromosome 5 in a patient with a prolonged aPTT.

Background : Humeral head osteonecrosis is a frequent complication of Sickle Cell Disease (SCD). Little is known about shoulder arthroplasty indications and results in these patients. The aim of this retrospective review is to compare the actual indications and results for SCD to a literature review.

Methods : All shoulder arthroplasties performed on SCD patients between 2016 and 2022 have been evaluated. 17 shoulders in 15 patients were followed up for 2.5 years. Indications, functional and radiological results, and complications were compared to a literature review.

Results : The Constant score significantly improved by 35 points (p =0.016). Patients were finally satisfied with a mean SSV evaluation at 72%. Post-operative complications due to SCD were frequent. There was a bilateral dramatic reverse prosthesis loosening in a patient with severe bone sclerosis due to necrosis. The use of pyrocarbon hemi-arthroplasty is promising and was never described in the literature for SCD shoulder osteonecrosis.

Discussion : Shoulder arthroplasty for collapse humeral head in SCD patients should be considered because of the significant functional improvement that can be obtained. Patients with SCD should be operated in a center with specialized surgeons surrounded by heamatologists to prevent specific complications.

This article provides insights into the current state of social media in the field of hematology-oncology. It highlights the increasing role of platforms like Twitter and Facebook in facilitating information sharing, patient support, and professional collaboration. The article emphasizes the challenges of maintaining accurate reliable content amidst the abundance of information. Additionally, it discusses the potential benefits of social media and fostering patient engagement, clinical trial recruitment, and knowledge dissemination among healthcare professionals and patients.

A 9-year-old boy came to our hospital complaining of headache, vomiting, abdominal pain. Physical examination revealed an increase in submandibular lymph nodes up to 1.5 cm, hepatomegaly.