The study to determine the effectiveness of the program Behavioural improve the level of Environmental Compliance for a sample of patients with viral hepatitis (C) due to the risk of hepatitis where liver injury affects all organs of the human body according to the carried out by the liver from a huge amount of jobs and involvement with members of the other for the success of its functions and reached a sample study (30) patients were divided into two groups (15) patients represent a sample pilot was selected to deliberate to ensure the availability of the conditions selected sample them and reluctant to National Institute of the liver to address the drug interferon was their consent to participate in the program of cognitive behavioral through interdependence between sessions mixing cognitive behavioral, which included the definition of injury and protective factors, treatment and use the mechanisms of treatment is cognitive to confront ideas and beliefs of patients negative associated with the future of the injury and the use of a method to relax and follow the approach of rational thinking and immunization against the pressure and the expression of feelings of patients to confirm the capacity of patients to cope and accept to continue the plan therapeutic approved by the doctors To determine the effectiveness of the program applied to and included the study sample control group compared to strong (15) patients subject to take a drug interferon only and use a researcher with the study tools included a measure of Environmental Compliance of the design of the researcher to assess the level of psychological adjustment and social development for patients in the two samples experimental and control groups before and after application of the program and to determine the effectiveness of the program to sample experimental and comparison of results Sample control The results of the study that there are significant differences in favor of measurement post test in the sample experimental subject for the program Cognitive Behavioral with continued eating interferon as a treatment chemical compared to sample the control subject to take a drug interferon as a treatment chemical only in the level of psychological adjustment and social, which refers the effectiveness of the program in improving the compatibility level of viral hepatitis patients (C).

Background and Aim: Egypt has high prevalence of HCV. The household contacts of HCV seropositive patients had been shown to have a high risk of HCV infection.

The aim was to determine the HCV infection outcome and genotyping among household contacts of patients in Upper and Lower Egypt.

Methods: In this multicentre study a total of 4891 individuals were recruited from Upper and Lower Egypt. The index HCV patients were 1106 cases while their household contacts were 3785 cases. All cases with HCV infection were confirmed by PCR HCV RNA technique as well as sequencing analysis of the 5′ UTR of HCV was performed and genotypes were recorded.

Results: The HCV prevalence among house hold contacts was 17.29 % and 19.17% while the spontaneous viral clearance (SVC) was 2.49% and1.55% in lower and Upper Egypt respectively.

Different genotypes and subtypes of HCV which were detected in Upper and Lower Egypt respectively: (genotype 4a ( 90.3% & 70.1%), 4m (4.8% & 11.8%) 4n (0.5% & 3.2%) 4o (0.2% & 2.9%) 4i (0.5% & 1.9%) 4v (0.8% & 1.2%) & 1a (2.9% & 8.3%) but 1g and 1b found in Lower Egypt with (0.3%) and didn’t detected in Upper Egypt. Genotype 4a was higher in Upper Egypt (90.3%) than in Lower Egypt (70.1%) and genotype 1a was higher in Lower Egypt (8.3%) than in Upper Egypt (2.9%).

Conclusion: Higher HCV prevalence in Household contacts in Upper more than lower Egypt while SVC was higher in Lower than Upper Egypt. Genotype 4 was more in Upper than Lower Egypt while genotype1a was increased in lower than Upper Egypt.