Background/Objectives: Conventional psychometric instruments generally show limited ability to correlate with circulating biological markers. ADNe® is a 29-item psychogenic instrument based on a neurotransmitter-weighted response framework, designed to model functional patterns of neurobiological activation rather than classify personality traits. This study aimed to explore whether ADNe® neurofactor scores are associated with plasma concentrations of cortisol, interleukin-6 (IL-6), and testosterone in healthy adults.

Methods: Twenty healthy volunteers (15 women, 5 men; mean age 30.3 ± 9.6 years, range 22–61) completed the ADNe® questionnaire and provided a peripheral blood sample on the same day. Plasma was isolated by centrifugation (400 × g, 5 min), and biomarker levels were quantified using ELISA. Statistical analyses included Spearman rank correlations and exploratory multiple linear regression models using the seven neurofactors as simultaneous predictors.

Results: Significant associations were identified between selected neurofactors and biomarkers. Sm (attentional amplitude) showed an inverse correlation with testosterone (ρ = −0.567; p = 0.022), while Mn (strategic acuity) was inversely associated with IL-6 (ρ = −0.489; p = 0.046). Exploratory multivariate models showed high apparent explanatory capacity within this dataset (R² = 0.848 for IL-6, 0.735 for testosterone, and 0.569 for cortisol). However, given the small sample size and the number of predictors included, these estimates should be interpreted with caution.

Conclusions: In this pilot study, ADNe® neurofactor profiles showed associations with circulating biomarkers, suggesting that this approach may capture dimensions related to physiological regulation. Nevertheless, the findings are exploratory and may be influenced by overfitting and un-measured confounding variables. Independent replication in larger, pre registered studies with appropriate validation strategies will be necessary to confirm the robustness and generalizability of these results.

Lung squamous cell carcinoma (LUSC) is one of the most common subtypes of non-small cell lung cancer, accounting for approximately 25-30%. Chemotherapy remains one of the main treatment options for lung squamous cell carcinoma, but long-term use often leads to the development of drug resistance in LUSC, resulting in reduced chemotherapy efficacy. This report described a patient with lung squamous cell carcinoma who underwent albumin paclitaxel+carboplatin chemotherapy after being diagnosed with right primary bronchogenic carcinoma (LUSC, cT3N1M0 stage IIIA). Two months later, examination revealed that the tumor volume seemed to have increased, indicating the development of chemotherapy resistance. Phosphorylation omics analysis was performed on adjacent and tumor tissues of patients, and it was found that the phosphorylation abundance of some loci in genes such as TRAF2 (T7) and PAK2 (S2) changed, which may be a key factor in the development of chemotherapy resistance.

Di(2-ethylhexyl) phthalate (DEHP) is recognized as an endocrine-disrupting compound and is widely adopted as a plasticizer. Evidence links its reproductive toxicity to the tumor suppressor PTEN, genomic stability is crucially maintained by DNA damage repair (DDR). PTEN loss promotes DNA damage accumulation and cellular senescence. Resveratrol (RES), a natural polyphenol, exhibits antioxidant and anti-inflammatory activities and shows protective potential for the male urogenital system. Nevertheless, the mechanisms associated with testicular senescence due to DEHP exposure and RES protection remain incompletely understood. This study employed in vivo and in vitro models, including cell viability assays, testosterone ELISA, cell cycle distribution analysis, senescence marker staining, Western blotting, and PTEN modulation. DEHP exposure significantly reduced testosterone levels in rat testis and TM3 cells, which was ameliorated by RES. DEHP/MEHP treatment upregulated senescence markers (β-Gal, p21, p16, γH2AX), downregulated PTEN and CDK2, and increased p-CHK2. These changes were reversed by RES. PTEN overexpression attenuated MEHP-induced senescence, G1 arrest, and testosterone reduction, while PTEN inhibition abolished RES protection. These findings elucidate the mechanism by which RES protects against DEHP-induced senescence via inhibiting PTEN loss.

Brassica carinata is an important underutilized cruciferous vegetable that has strong potential for reducing food insecurity and boosting crop production due to its drought and pest resistant qualities. The vegetable supported a total of 5128 colonies with bacterial colonies higher at 4440 while fungal colonies were 688. Bacterial colonies were isolated in high
amounts at 10-1 while fungal colonies were highly recovered at 10-5. Bacterial results revealed that 37% were circular shaped while rhizoid form were lowest at 4.5% and the majority were gram positive. The Bacilli bacteria were more dominant over the cocci shaped bacteria. The roots harbored higher number of nitrogen fixing bacteria at 75% of the isolated endophytes as compared to roots and stem. Additionally, the roots contributed 60% of the endophytes that had the ability to solubilise phosphates. Antifungal results showed that four endophytes inhibited the growth of Colletotrichum higginsianum. Fungal isolates exhibited more Fusarium species isolated but Aspergillus spp had the highest phosphorous stabilization efficiency (PSE). One Fusarium spp had the capacity to inhibit the growth of C. higginsianum.

A total of 9347 fungal and bacterial endophytes were isolated from the roots, stem and leaves of chia plant. Roots harbored more number of fungal endophytes than either stem or leaves whereas stem supported more number of bacterial endophytes than either roots or leaves. The nutritious plant supported more of gram negative compared to gram positive bacterial endophytes. The most common bacteria isolated were Pseudomonas Bacillus, and Cocci. The fungal endophytes isolated from root, stem and leaves of the chia plant showed the presence of Penincillium, Aspergillus, Fusarium, and Macrophomina spps. Dominant fungal endophyte was Aspergillus spp. which was found in all the plant parts instigated. Roots of the plant possessed maximum nitrogen fixers followed by stem and leaves. A proportion of 55% for the bacterial endophytes isolated from the plant chia plant were able to fix nitrogen whereas 25% were able to solubilize phosphorous. The phosphate solubilization efficiency was found to be highest for the Aspergillus spp at 83%.