Background : There is no clear negative impact of Medication Overuse Headache (MOH) on Quality of Life (QoL).

Objective : The aim of this study was to identify clinical and headache-related parameters that directly affect the HRQoL of MOH patients.

Patients and methods: A total of 183 patients (111 men and 72 women) first diagnosed with MOH and 81 healthy subjects (22 men and 59 women) in the Control Group (CG) were enrolled in this study. The age of the study subjects ranged from 18 to 71 years. HRQoL was assessed using the Short Form-36 (SF-36), which includes the Physical Composite Score (PCS), Mental Composite Score (MCS) and Total Score (TS).

Results : The HRQoL of all patients (PCS, MCS, TS) was lower in the MOH than in the CG (p < 0.001). In the MOH, depression itself was a risk factor for all aspects of HRQoL according to the PCS (B = -0.70, 95% CI -1.32 - 0.08, p = 0.027); for the MCS (B = -0.71, 95% CI -1.14 - - 0.29, p = 0.001); and for the TS (B = -0.69, 95% CI -1.16 - - 0.22, p = 0.005)), with female sex being an associated risk factor only for PCS (B = -15.47, 95% CI -26.79 - - 4.14, p = 0.008). The results did not reveal a predictive role of anxiety, stress, or ruminative style of thinking for HRQoL in MOH patients (p > 0.05).

Conclusion : Screening for depression among MOH patients and treatment could be useful for improving their HRQoL.

Glioblastoma multiforme (GBM) is the most aggressive and most common type of cancer originating in the brain. In this publication we discuss our approach to support the GBM standard therapy (surgery, chemotherapy and radiation) by the administration of donkey milk (200 ml per os and day) as well as by the application of the neuroleptic drug quetiapine. Our therapeutic strategy can easily be tested in a clinical context because quetiapine is often routinely applied during tumor therapy in order to suppress depressions. Donkey milk is known to stabilize the immune system which is strongly compromised in the case of GBM patients under a standard therapy. Since it is discussed in the literature that donkey milk and quetiapine have anti-tumor properties, especially, in the case of GBM, we focus on certain compounds in donkey milk and their potential interference with quetiapine. These compounds are proteins with a carbohydrate specificity, e. g. lectins which are able to bind galactose residues in a specific way, such as human galectin-3. Such lectins and their ligands are related to crucial tumor migration pathways. This can be achieved by a multimodal strategy combining molecular modeling with histological and radiological examinations. In addition, Atomic Force Microscopy (AFM) and X-ray nanotomography with synchrotron beams are extremely helpful because they enable a high-resolution three-dimensional imaging of cell- and tissue-probes. In combination with molecular modelling