Though rare, angiosarcomas are one of the most common tumors to arise following radiation therapy for the treatment of malignancies, such as breast cancer and Hodgkin’s lymphoma. Investigation of radiation-associated angiosarcomas has always proven difficult due to the extremely low incidence. This means that case studies are the predominant type of investigation found in the literature. Breast cancer treatment can lead to chronic lymphedema due to the dissection of axillary lymph nodes, as well as radiation treatment, often following conservative breast surgery. Due to these risk factors, breast cancer patients are at an increased risk of development of angiosarcoma. We present a case of breast angiosarcoma that developed after radiation therapy for breast ductal carcinoma. In this case, there were multiple metastases and recurrences in the involved breast, as well as development of angiosarcoma in the opposite breast. We also provide a brief review of the literature.