Background: The factors affecting survival were evaluated in patients aged ≥ 70 years with Non-Small Cell Lung Cancer (NSCLC) treated with definitive Radiotherapy (RT).

Methods: Between January 1996 and April 2012, 52 patients were treated. The median age was 73 (range 70-80) and 73% and 75% of patients with stage III according to AJCC 2002 and AJCC 2010 staging, respectively. Radiotherapy was performed median 6160 cGy (range: 3600-6660 cGy) and CHE were given 75% of the patients.

Results: Median follow-up was 12.5 (range: 2.5-103) months. Median overall (OS) and Disease-Free (DFS) Survival were 22 and 18.5 months, respectively. Radiotherapy related death was not observed. In Univariate analysis; AJCC 2002 stage I-II, RT dose, RT duration, for OS and RT dose, RT duration, neoadjuvant CHE ≤ 3 cycles, complete response, ≥ 4 cycles of CHE for DFS were significant (p <0.05). In multivariate analysis, RT duration > 49 days related with higher RT dose (≥ 60 Gy) were found a positive impact on OS (HR: 3.235, 95% CI: 1:25 to 8:32 p = 0.01).

Conclusion: In our study, elderly patients with NCSLC can be given ≥ 60 Gy without complications and was seen positively impact on survival.

Introduction : Throughout history it has been proven that electromagnetic fields at uncontrolled levels can be harmful to health. The Computerized Axial Tomography (CT) is a high electromagnetic field generator. In TAC areas where workers are exposed to these radiations for extended periods of time, it is necessary to keep not only ionizing radiation under control, but also non-ionizing radiation.

Goals: Carry out magnetic field measurements in a CT area in a hospital in the city of Havana, compare them with international standards and check the state of the electromagnetic environment.

Methods: The magnetic field measurements were carried out using a gaussmeter located one meter above the floor level and punctually meter by meter. To verify the state of the environment, the recommendations of the International Commission on Non-Ionizing Radiation Protection (ICNIRP) in 2010 were used as a point of comparison.

Results: The results showed values below those recommended by the ICNIRP, but very close to those provided by some authors as causing leukemia.

Conclusions: It was concluded that the non-ionizing radiation values obtained in µT do not exceed those recommended by this commission, with respect to occupational exposure, but strict surveillance must be maintained.

Pancreatic Ductal Adenocarcinoma (PDAC)-associated Neural Remodeling (PANR) is a common and characteristic feature of PDAC that is related to generation of pain, poor prognosis, and tumor recurrence. However, the molecular mechanisms in cancer cells and nerves within PANR have not previously been comprehensively analyzed. Exosomes or circular RNAs (circRNAs) have been reported to exert important regulatory and/or communication roles in PANR, which is characterized by pathogenic modifications to the peripheral nervous system that enhance metastatic capacity of PDAC. In our study, an in vitro model of PANR was constructed through a co-culture system comprising PDAC cell lines and murine Dorsal Root Ganglia (DRG) as the neuronal element. In addition, using circRNA sequencing, we identified that circ0009128 was significantly up regulated in exosomes derived from cell culture media and PTC patient serum. Futher more, using an in vitro model of PANR, circ0009128 could enter murine DRG cells through exosomes, and murinecirc0009128 induced PANR. Mechanistically, circ0009128 contained multiple miRNA binding targets, functioning as a sponge for miR-30c-5p, which in turn promoted expression of UNC5C. These results concluded that exosomal circ0009128 promoted PANR via the miR-30c-5p/UNC5C axis, identifying that it may contributed to PDAC progression.